Manufacturing of Hard Gelatin Capsules - Lifevision Chandigarh has been playing a vital role in the pharmaceutical sector by manufacturing of Hard Gelatin Capsules for the last many years. We are an ISO-certified business that produces goods in accordance with WHO and GMP guidelines to meet both domestic and international quality requirements. We produce a wide variety of pharmaceutical products including tablets, capsules, injections, ointments, syrups, and many more. We have developed a solid reputation as one of the top Hard Gelatin Capsule manufacturers and suppliers in India that offers highly effective medicines at reasonable prices.

Lifevision Chandigarh manufacturer of hard gelatin capsules in India supplies capsules to the pharmaceutical sector, which are then filled in a separate process. Before going into the step-by-step method required for the stringent quality control in the production of gelatin capsules, let's take a closer look at the raw materials that go into making hard gelatin capsules.

Increasing Demand of Hard Gelatin Capsules in India

India is one of the major manufacturers of pharmaceutical products in the world. The increasing requirement of hard gelatin capsules is evident from the above statement. As a WHO-GMP certified Third Party Manufacturing partner located in Chandigarh, India, Lifevision is well placed to cater to this market.

India, together with USA and Germany, belongs to the category of the top three manufacturers in the worldwide hard gelatin capsules segment. India's market for empty capsules will reach an estimated $0.28 billion value mark by 2026 on the back of rising pharmaceutical exports, higher use of nutraceuticals, and improving healthcare access in the country. Fortune Business Insights
The share of hard gelatin versions remains dominant at more than 84%, whereas over 65% of all capsule-form medicines utilize hard gelatin caps. Source: Mordor Intelligence

What are Hard Gelatin Capsules?

Hard gelatin capsules are solid dosage forms that contain one or more drugs and/or inactive substances inside a small shell. They are made mostly of gelatin and have two parts: a body that holds the drug and diluent and a cap that is about half the length of the body. Most capsule products produced today are made from firm gelatin. The use of hard gelatin capsules in the preparation of solid dosage forms is considered to be approximately ten times higher than that of soft gelatin capsules.

Step-by-Step Manufacturing Process

Lifevision Chandigarh is a company that uses the industry-standard dip-coating method. This can basically produce up to 150,000 capsules per hour on automated filling lines:

Preparation of Gelatin Solution - Gelatin solution is prepared by dissolving the gelatin in demineralized water at 60–70°C. The colorants and plasticizers are added to the gelatin solution, and the mixture is degassed.

Dip-Coating - Pre-greased stainless steel pins are dipped into the gelatin solution. Timings determine shell thickness, which averages 100-150 microns.

Rotation - Rotating the coated pins by 180° provides even distribution of the gelatin on the pins, avoiding pooling at the end.

Drying - Pins are put into kilns that control the levels of humidity in order to achieve a 12-16 percent moisture content.

Stripping and trimming - Stripped pins are then cut to specific sizes and shapes.

Assembly - The body and cap are brought together by telescoping and are pre-closed with locking rings for tamper-resistant seal.

Printing & Packaging - The capsules are printed with the product details on them and are stored under special conditions.

Raw material for Manufacturing Hard Gelatin Capsules

Gelatin makes up a major portion of the hard gelatin capsule shell. In addition to gelatin, it may also contain substances such as plasticizers, colorants, opacifying agents, and preservatives that either help form the capsules or increase their functionality. Depending on storage conditions, the water content in hard gelatin capsules can range from 12 to 16 percent. Here are some of the steps that are followed in the manufacturing process of hard gelatin capsules -

Gelatin - The most popular and widely used substance used to make hard capsule shells is gelatin. It is a collective term for a mixture of purified protein fractions obtained from collagen taken from animal skin, white connective tissue, and bones by irreversible hydrolytic extraction.

Plasticizer - Plasticizers are given to gelatin to make the polymer more malleable and reduce its hardness. Glycerin and polyhydric alcohol are typical examples of plasticizers. Water, which is naturally found in gelatin, is also an excellent plasticizer.

Colorants - Hard gelatin capsules are usually colored to improve their visual properties and serve as a way to differentiate between different products. The use of dyes must comply with all legal requirements in the countries where the product will be marketed.

Opacifying agent - Clear gelatin can be made opaque by adding an opacifier. Opaque capsules may be used to protect them from light or hide the contents.

Preservative agents – Preservatives used to be added to hard capsules as an in-process aid to prevent microbial contamination during production. Manufacturers that used to comply with GMP requirements in their facilities no longer use them.

Why Choose Lifevision Chandigarh for Manufacturing of Hard Gelatin Capsules?

A reputed manufacturer of Hard Gelatin capsules, Lifevision Chandigarh offers pharmaceutical product manufacturing services at the most competitive prices. We provide DCGI-certified products of the highest quality to pharma companies. Our research team is always trying to bring best-in-class product variety to the market and also putting in great efforts to introduce new developments for the benefit of the customers. We are the top Hard Gelatin Capsules manufacturer and supplier in India owing to several other criteria:

We make a variety of things in a single day.
A knowledgeable and professional team of employees is hired.
The products are produced as per the requirements and quality standards of the customers.
The packing is of high quality.
Because of our large warehouse space, we can ship large orders quickly.
Modern technology has been deployed to boost manufacturing effectiveness.
The entire formulation process is carried out in a clean setting.
The production process is carried out according to ISO regulations.

Quality Control Standards at Lifevision Chandigarh

Each batch is extensively tested in accordance with WHO GMP standards and IP standards, including disintegration tests (30 min in simulating gastric juice), weight variation test (+/-7.5%), moisture analysis (12-16%)%, leakage tests, size checks, microbial limits tests, and automatic visual inspections. Lifevision Chandigarh’s no-loop quality control system prevents any product that does not meet specifications from progressing through production processes.

Contact Details

Name: Lifevision Chandigarh

Address: Plot No. 11-12, Dainik Bhaskar Building, Sector 25-D, Chandigarh- 160014, India

Phone Number: +91-9317777888

Frequently Asked Questions

What are hard gelatin capsules made of?

The hard gelatin capsule is composed of gelatin (which comes from collagen in animals), plasticizers such as glycerin, dyes, and an opacifier such as titanium dioxide. The moisture content in the shell must be between 12 to 16% w/w.

What is the difference between hard and soft gelatin capsules?

The former consists of two parts and contains dry powder or dry granules at 12-16% moisture content. The latter contains liquid medication at around 30% moisture content in one piece. In the pharmaceutical industry, hard gelatin capsules are much more popular than soft gelatin capsules. Lifevision Chandigarh produces both kinds. Check out our Soft Gelatin Capsules range.

Who is the best manufacturer of hard gelatin capsules in India?

Lifevision Chandigarh is a WHO-GMP, ISO-certified, and DCGI-licensed manufacturer of hard gelatin capsules. We provide competitive prices on all capsule sizes from 000 to 5, along with contract pharmaceutical manufacturing services in India.

What is the MOQ for outsourcing of capsules from LifeVision?

At LifeVision, we provide tailor-made solutions in terms of MOQ to suit the requirements of our customers big and small. Please contact us on +91-8062750200 or enquiry@lifevisionhealthcarechd.com with your specifications, GST number, and drug license.

What is tested during the quality control test for hard gelatin capsules?

Test includes disintegration (upto 30 mins), weight variation (7.5 %), moisture content (upto 12-16 %), leakage test, microbial limit, dimensional test at 20-25°C / 45-60% humidity as per WHO-GMP standards and Indian Pharmacopoeia guidelines